Computational Biophysical Chemistry

Hansmann Group

Contact us at:
Dept. of Chemistry and Biochemistry
University of Oklahoma
101 Stephenson Parkway
Norman, OK 73019-5251,USA

Tel:  -405-325-2386
Fax:  -405-325-6111
E-mail: uhansmann at

Workalemahu Berhanu


Postdoctoral Associate


Stephenson Life Sciences Research Center 3000, 101 Stephenson Parkway, Norman, OK 73019-5251, USA





Bimolecular simulation and computer aided drug design


1992-1996, Bachelor of science, Pharmacy Addis Aabab University, Ethiopia

2003-2005, MSc degree, Pharmaceutical Analaysis Addis Ababa University, Ethiopia

2007-2011, PhD, University of Central Florida, USA

Jan 2012-, Post Doctoral researcher, University of Oklahoma, USA


Workalemahu M. Berhanu & Artem E. Masunov .,
" Unique example of amyloid aggregates stabilized by main chain H-bond instead of the steric zipper: Molecular dynamics study of the amyloidogenic segment of amylin wild-type and mutants (NNFGAIL) segment of amylin aggregate. ",
Journal of Molecular Modeling, , published online: 28 May 2011; DOI 10.1007/s00894-011-1030-7. (2011)

Workalemahu M. Berhanu & Artem E. Masunov .,
"Molecular dynamic simulation of wildtype and mutants of the polymorphic amyloid NNQNTF segments of elk prion: structural stability and thermodynamic of association",
Biopolymers,95, 573-590 (2011)

Workalemahu M. Berhanu & Artem E. Masunov .,
"Alternative packing modes as basis for amyloid polymorphism in five fragments ",
Peptide Science, , . Article first published online: 23 OCT 2011 | DOI: 10.1002/bip.21731

Workalemahu M. Berhanu & Artem E. Masunov .,
"Control over aggregation stability and fast release for improving the insulin formulation: Molecular Dynamics study of the amyloid oligomer models. ",
Journal of Molecular Modeling , published online: 15 June 2011; DOI 10.1007/s00894-011-1123-3

Workalemahu M. Berhanu & Artem E. Masunov .,
"Can Molecular Dynamics Simulations assist in design of specific inhibitors and imaging agents of amyloid aggregation? Structure, stability and free energy predictions for amyloid oligomers of VQIVYK, MVGGVV and LYQLEN.",
Journal of Molecular Modeling, 17 , 2423-426 (2010)

Workalemahu M. Berhanu, Ivan A. Mikhailov & Artem E. Masunov .,
"Are Density Functional Theory predictions of the Raman spectra accurate enough to distinguish conformational transitions during amyloid formation?.",
Journal of Molecular Modeling, 16, 1093-1101 (2010)

Workalemahu M. Berhanu &, Artem E. Masunov,
"Natural polyphenols as inhibitors of amyloid aggregation. Molecular Dynamics study of GNNQQNY heptapeptide decamer",
Biophysical Chemistry, 149, 12-21 (2010)

Workalemahu Mikre, & Abd El-Maaboud I. M. ,
"Determination of Lamivudine and Stavudine in pharmaceutical preparations using chemometrics-assisted spectrophotometry.",
Saudi Pharmaceutical Journal,17, 275-281 (2009)

Nigus Dessalew & Workalemahu Mikre,
"On the paradigm shift towards multitarget selective drug design",
Current Computer Aided Drug Design,4, 76-90 (2008)

Nigus Dessalew, Workalemahu Mikre & Ariaya Hymete,
"Multitarget Selective Antidepressants Design: Latest Developments, Opportunities and Challenges.",
Central Nervous System Agents in Medicinal Chemistry,8, 131-142 (2008)

Workalemahu Mikre, Jens Rohloff & Ariaya Hymete,
"Volatile constituents and antioxidant activity of essential oils obtained from important aromatic plans of Ethiopia.",
Journal of Essential Oil Research,18, 465-4743 (2007)